These days there is much talk about the importance of the 1: 1 ratio in cannabinoid products (whether natural or laboratory) intended for therapeutic use.
The 1: 1 ratio refers to the ratio between the two main cannabinoids existing in the plant, that is, between thc (delta-9-tetrahydrocannabinol) and cbd (cannabidiol).
It is intuited that the favorable profile of this ratio exists for two fundamental reasons.
- On the one hand, we have the modulating effect that cbd exerts on the initial euphoriating effect of thc, or initial high. This initial high is not always pleasant for patients, especially for those who are not used to using cannabis. Until relatively recently it was thought that the best marijuana for therapeutic use were those with a higher percentage of thc, regardless of the other cannabinoids present in the sample. As an example we have the Israeli company Tikum Olam, which has a variety that reaches up to 23% thc, and its effect is so powerful that it is to be assumed that not all patients willingly accept this type of medication. It is known that the higher the level of cbd in the sample, the lower the initial high effect caused by thc. And it seems that the 1: 1 ratio is the one that achieves the best effects in this regard. Since Sativex was approved (and remember that the Sativex ratio is 1: 1), this has been the general trend: look for the 1: 1 ratio for medicinal use.
- If, on the one hand, CBD effectively modulates the initial psychic effect of thc, The medicinal properties of CBD itself seem to be the second reason why this ratio is so beneficial. We cannot forget that CBD has important anti-inflammatory and antioxidant properties, among others, which would give an important complementary touch to the pharmacological cocktail. In addition, CBD has good therapeutic potential in diseases such as rheumatoid arthritis, diabetes, alcoholism, post-traumatic anxiety disorder, epilepsy, neurological disorders, antibiotic resistant infections. In addition, it has neuroprotective effects and antitumor potential, inhibiting tumor neoangiogenesis or, what is the same, the growth of new blood vessels around the tumor with the function of nourishing it.
Renaming Tikun Olam, just to say that now they are working with two species with minimal levels of thc and high levels of cbd. Avidekel and Rafael were the names chosen for these two new genetics, the last named after the discoverer of thc, Professor Rafael Mechoulam.
There are seed banks that have been betting for a long time on the new relevance that CBD is adopting in the cannabiotypes of its “medicinal” species.
A bank called Cbd Crew has developed several species with thc: cbd ratios close to 1: 1. As is almost always the case when a new species is brought to market, the new ones are based on old acquaintances. Thus, we have Cbd Nordle (thc: 6.43% – cbd: 8.97%), Cbd Shark (thc: 6.33% – cbd: 7.28%), Cbd Critical Mass (thc: 5, 49% – cbd: 8.13%), Cbd Outdoor Mix (thc: 6.82% – cbd: 11.6%), Cbd Skunk Haze (thc: 12.5% - cbd: 11.12%) and Cbd Yumy (thc: 8.09% – cbd: 9.01%), all being feminized varieties.
Highlight the important work that the Canna Foundation is doing thanks to the accuracy of the analyzes it performs on cannabis samples, giving the scientific community very valuable data on the cannabiotype of the different species. The most interesting from my point of view is Cbd Sweet and Sour Widow, which maintaining percentages of thc: 8.31% and cbd: 10.47% is regular, so there is the possibility of choosing good males for future crosses with other species.
There may even be those who give more importance to the cbd content than to the thc content and look for species with higher percentages of the first. There is an initiative called the CBD Project that gathers notifications from around the world regarding varieties with high CBD content. Thus, we have that in California a grower named Lawrence Ringo got a species called Sour Tsunami, which in one out of four times achieves high levels of CBD (10-11%) compared to THC (6-7%).
There are even those who have done cannabinoid analyzes on the leaves of the plant in a vegetative state with surprising results. This is what happened to Wilson Linker, from the Steep Hill Laboratory, who, taking the variety Harlequin, found by gas chromatography percentages of 4% cbd and 2% thc.
Another variety analyzed in this project is the Omrita 3 RX, which, after being analyzed by CW Analytical, Botanical Analysis and Steep Hill Lab, consistently presented percentages of 9-12% cbd and 5-7% thc. Californian passion for the importance of CBD led to the analysis of the CBD: thc ratio in the same variety throughout the flowering phase. The variety chosen for this work was the Jamaican Lion’s, and it was analyzed six times from the beginning of flowering, presenting proportions that varied from 9.7% cbd and 5.8% thc, to 8.7% cbd and 6.8% thc. The highest cbd value found refers to the eighth week of flowering, being in the ninth week when the thc / cbd ratio was closer to the much desired 1: 1.
A Spanish bank, Resin Seeds, contributes to this project with its variety Cannatonic, with a 1: 1 ratio (6% thc and 6% cbd). Independent experiments obtained four different phenotypes, from the same Cannatonic package. One of the phenotypes resulted in a specimen that after being analyzed revealed percentages of cbd higher than 13%, with approximately half of thc (these values were obtained by two different laboratories).
Reggae Seeds, also a Spanish seed bank, contributed its variety Juanita the Lagrimosa, which after being analyzed by the Canna laboratories gave a ratio thc: 6.8% and cbd: 8.8%. In fact, this variety was the first Spanish genetics to present this 1: 1 ratio. This, together with its regular genetics, gives it many ballots to be the origin of the previously mentioned Cannatonic, which, due to being feminized, loses interest to take advantage of the genetic characteristics of the species by making non-asexual crosses.
Another species with high cbd content has its origin in Montana. It is known by the name of Misty, and in the laboratory it gave a percentage of 10% of thc and 7% of cbd. Good Medicine is the name by which another variety of Montana with excellent medicinal properties. Expecting to find high levels of thc, it was analyzed in the Missoula Cannab Analyzes laboratories, giving a ratio of 8.2% thc and 9.03% cbd, which left the growers who brought this genetics to the laboratory more than surprised.
On the other hand, and leaving aside the samples in the raw state, we have the dyes with a 1: 1 ratio, such as the one known by the name of Tranquility, and that is presented as a medicine based on cannabinoids that contain 50% thc and 50% cbd. Its main indications are pain, both acute and chronic, in those patients who want a medium degree of psychoactivity; is available to patients residing in California.
Therefore, whether in a nebulizer, in a pure vegetable state or in tinctures, the tendency is to find a balance between thc and cbd when the desired use is medicinal, not only because of the medicinal properties that cbd has per se but also because of the important modulating effect it exerts on the initial high of thc.